The Ohio River is the largest tributary of the Mississippi River, at nearly 1,000 miles from its headwaters in Pittsburgh, Pennsylvania to its mouth on the Mississippi River at Cairo, Illinois. The Ohio flows through or along the border of six states including Pennsylvania, Ohio, West Virginia, Kentucky, Indiana and Illinois.
| Month | Number of Cruises | From Price |
|---|---|---|
| May 2025 | 1 cruises | $7,775 |
| Jul 2025 | 5 cruises | $4,610 |
| Aug 2025 | 3 cruises | $4,610 |
| May 2026 | 1 cruises | $7,775 |
| Jun 2026 | 1 cruises | $9,015 |
| Jul 2026 | 1 cruises | Call For Price |
| 8 Night Ohio River Cruise from Pittsburgh | Duration | Priced from |
|---|---|---|
|
8 Nights |
$5,275per person
(double occupancy) |
| 8 Night Ohio River Cruise and Land Tour from Louisville | Duration | Priced from |
|---|---|---|
American Heritage 3 Sail Dates: 7/18/25; 8/1/25; 8/15/25; See More Starting Port: Louisville, Kentucky, United States Ports of Call: Louisville, Cruising the Ohio River, Cincinnati, Maysville, Cruising the Ohio River, Marietta... |
8 Nights |
$4,610per person
(double occupancy) |
| 8 Night Ohio River Cruise and Land Tour from Louisville | Duration | Priced from |
|---|---|---|
|
American Melody 3 Sail Dates: 7/11/25; 7/25/25; 8/8/25; See More Starting Port: Louisville, Kentucky, United States Ports of Call: Louisville, Cruising the Ohio River, Cincinnati, Maysville, Cruising the Ohio River, Marietta... |
8 Nights |
$5,275per person
(double occupancy) |
| 11 Night Great Smoky Mountains National Park Cruise and Land Tour from Knoxville | Duration | Priced from |
|---|---|---|
|
11 Nights |
$7,775per person
(double occupancy) |
| 8 Night Ohio River Cruise from Pittsburgh | Duration | Priced from |
|---|---|---|
|
|
8 Nights |
$4,610per person
(double occupancy) |
